Christianization of Talibon started long before the arrival of Miguel Lopez de Legazpi in 1565. This was gleaned from the archival researches of Rev. Fr. Jose Maria S. Luengo, Ph.D., priest historian and founder of the Mater Dei College of Tubigon, Bohol. In 1852, a permanent church was constructed now known as the Most Holy Trinity Cathedral.
Therefore, the church of Talibon by chronology, organization and operation became the cradle of Christianity in Bohol. Over two centuries passed, Talibon as a parish was created under the patronage of the Most Holy Trinity. Fr. Ramon de Santa Ana, O.R.S.A. became the first parish priest.